Cell Signaling Ki-67 (D3b5) Rabbit mAb (Mouse Preferred; Ihc Formulated)

Name: Cell Signaling Ki-67 (D3b5) Rabbit mAb (Mouse Preferred; Ihc Formulated)
SKU: CSIG-12202T
Price: 149.48 USD

List Price $149.48 Your Price $149.48

Cell Signaling Ki-67 (D3b5) Rabbit mAb (Mouse Preferred; Ihc Formulated) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-12202T

MFG.PART: 12202T

UNSPSC: 41116111

Manufacturer: Cell Signaling

Description

Size	20 µl
Reactivity	M
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Immunohistochemistry (Paraffin): 1:200 - 1:800}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Ki-67 (D3B5) Rabbit mAb (IHC Formulated) recognizes endogenous levels of murine Ki-67 protein. It will also detect endogenous levels of human Ki-67 protein; however, Ki-67 (D2H10) Rabbit mAb #9027 is recommended for the detection of human Ki-67 protein in paraffin-embedded tissues.
Species Reactivity	Mouse
Source/Purification	Monoclonal antibody is produced by immunizing animals with a recombinant protein specific to the amino terminus of Ki-67 protein.
Background	Ki-67, named after the location where it was discovered (Kiel University, Germany), is a nuclear nonhistone protein (1) that is universally expressed among proliferating cells and absent in quiescent cells (2). Ki-67 detects proliferating cells in G1, S, G2, and mitosis, but not in the G0 resting phase. Research studies have shown that high levels of Ki-67 are associated with poorer breast cancer survival (3). Research studies have explored the use of Ki-67, along with other markers, as potential prognostic or predictive markers in breast cancer and other malignant diseases (4).

Specifications