Cell Signaling Cdk7 (Mo1) Mouse mAb

Name: Cell Signaling Cdk7 (Mo1) Mouse mAb
SKU: CSIG-2916T
Price: 144.43 USD

List Price $144.43 Your Price $144.43

Cell Signaling Cdk7 (Mo1) Mouse mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-2916T

MFG.PART: 2916T

UNSPSC: 41116111

Manufacturer: Cell Signaling

Description

Size	20 µl
Reactivity	H R
Sensitivity	Endogenous
Molecular Weight (kDa)	40
Source/Isotype	Mouse IgG2b
Application/Dilution	{Western Blotting: 1:2000, Immunoprecipitation: 1:200, Immunohistochemistry (Paraffin): 1:500}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	CDK7 (MO1) Mouse mAb detects endogenous levels of total CDK7 protein. The antibody does not cross-react with other CDKs.
Species Reactivity	Human, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant human CDK7. The epitope corresponds to a region surrounding Gln320 of human CDK7.
Background	CDK-activating kinase (CAK) is a complex of CDK7 and cyclin H. The complex is involved in cell cycle regulation by phosphorylating an activating residue in the T-loop domain of cdks (1). Regulation of CAK activity is mediated by T-loop phosphorylation and by association with MAT1, both of which enhance its kinase activity toward the CTD of RNA polymerase II (2,3) and other substrates such as p53 (4). CAK is an essential component of the transcription complex TFIIH and may interact directly with TFIIH helicases (5).

Specifications