Cell Signaling Ki-67 (8d5) Mouse mAb

Name: Cell Signaling Ki-67 (8d5) Mouse mAb
SKU: CSIG-9449T
Price: 144.43 USD

List Price $144.43 Your Price $144.43

Cell Signaling Ki-67 (8d5) Mouse mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-9449T

MFG.PART: 9449T

UNSPSC: 41116111

Manufacturer: Cell Signaling

Description

Size	20 µl
Reactivity	H
Sensitivity	Endogenous
Source/Isotype	Mouse IgG1
Application/Dilution	{Immunohistochemistry (Paraffin): 1:800 - 1:3200, Immunofluorescence (Immunocytochemistry): 1:6400 - 1:25600, Flow Cytometry (Fixed/Permeabilized): 1:100 - 1:400}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. For a carrier-free (BSA and azide free) version of this product see product #62548.
Specificity/Sensitivity	Ki-67 (8D5) Mouse mAb recognizes endogenous levels of total Ki-67 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human Ki-67 protein.
Background	Ki-67, named after the location where it was discovered (Kiel University, Germany), is a nuclear nonhistone protein (1) that is universally expressed among proliferating cells and absent in quiescent cells (2). Ki-67 detects proliferating cells in G1, S, G2, and mitosis, but not in the G0 resting phase. Research studies have shown that high levels of Ki-67 are associated with poorer breast cancer survival (3). Research studies have explored the use of Ki-67, along with other markers, as potential prognostic or predictive markers in breast cancer and other malignant diseases (4).

Specifications