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Sigma-Aldrich Substance P - Cas 33507-63
List Price $88.16 Your Price $88.16
Sigma-Aldrich Substance P - Cas 33507-63-0 - Calbiochem - SIAL (Additional S&H Or Hazmat Fees May Apply)
NETA PART: SIAL-05-23-0600-1MG
MFG.PART: 05-23-0600-1MG
UNSPSC: 12352200
Manufacturer: Sigma-Aldrich
Quality Level
100
assay
≥96% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
color
white
solubility
5% acetic acid: 1 mg/mL
shipped in
ambient
storage temp.
−20°C
InChI
1S/C63H98N18O13S/c1-37(2)33-45(57(89)74-41(53(68)85)27-32-95-3)73-52(84)36-72-54(86)46(34-38-15-6-4-7-16-38)78-58(90)47(35-39-17-8-5-9-18-39)79-56(88)42(23-25-50(66)82)75-55(87)43(24-26-51(67)83)76-59(91)49-22-14-31-81(49)62(94)44(20-10-11-28-64)77-60(92)48-21-13-30-80(48)61(93)40(65)19-12-29-71-63(69)70/h4-9,15-18,37,40-49H,10-14,19-36,64-65H2,1-3H3,(H2,66,82)(H2,67,83)(H2,68,85)(H,72,86)(H,73,84)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,90)(H,79,88)(H4,69,70,71)/t40-,41-,42-,43-,44-,45-,46-,47-,48-,49-/m0/s1
General description
Neuropeptide found in high concentrations in the gut. When released from afferent nerves, causes a neurogenic inflammatory response, including mast cell degranulation. Induces Ca2+ mobilization. Reported to activate goα, gq/11α, and gsα subunits in CHO Cells via activation of substance P receptors. Also reported to induce superoxide production in neutrophils.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Substance P receptors
Substance P receptors
Product does not compete with ATP.
Reversible: no
Packaging
Yes
Warning
Toxicity: Standard Handling (A)
Sequence
H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH₂
Physical form
Supplied as a trifluoroacetate salt.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Roush, E.D., and Kwatra, M.M. 1998. FEBS Lett. 428, 291.
Chiwakata, C.B., et Al. 1996. Infect. Immun. 64, 5106.
Tanabe, T., et Al. 1996. Eur. J. Pharmacol. 299, 187.
Heath, M.J., et Al. 1994. J. Neurophysiol. 72, 1192.
Zhu, J., et Al. 1994. Eur. J. Pharmacol. 268, 279.
Garland, A.M., et Al. 1993. Soc. Neurosci. 19, Abstract 104.6.
Wei, J.Y., et Al. 1993. Soc. Neurosci. 19, Abstract 136.14.
Chiwakata, C.B., et Al. 1996. Infect. Immun. 64, 5106.
Tanabe, T., et Al. 1996. Eur. J. Pharmacol. 299, 187.
Heath, M.J., et Al. 1994. J. Neurophysiol. 72, 1192.
Zhu, J., et Al. 1994. Eur. J. Pharmacol. 268, 279.
Garland, A.M., et Al. 1993. Soc. Neurosci. 19, Abstract 104.6.
Wei, J.Y., et Al. 1993. Soc. Neurosci. 19, Abstract 136.14.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
wgk_germany
WGK 1
| SKU | SIAL-05-23-0600-1MG |
|---|---|
| Supplier Part Number | 05-23-0600-1MG |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Sigma-Aldrich |
| Temperature | F0 |
| ProductLine | SIAL |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 10.000000 |
| Lead Time | 9 |
| Hazardous | N |
| CAS Number | 33507-63-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |