Sigma-Aldrich Adenosine A2a Receptor Ago

A xanthin derivative that acts as a potent agonist of adenosine A_2A receptors (K_i = 27 nM). Exhibits reduced affinity for A_2B receptors (K_i = 67 nM), but offers greater selectivity over A_1R (K_i = 290 nM) and A_3R (88.8 µM). Exerts an anti-inflammatory effect during chronic inflammation and ameliorates the tissue damage associated with collagen-induced arthritis. Also shown to reduce CCR7 Protein Expression in THP1 macrophages. Shown to delay the progressive deterioration of motor performance and prevent a reduction in brain weight in murine model of Huntington′s disease.

A xanthin derivative that acts as a potent agonist of adenosine A_2A receptors (K_i = 27 nM). Exhibits reduced affinity for A_2B receptors (K_i = 67 nM), but offers greater selectivity over A_1R (K_i = 290 nM) and A_3R (88.8 µM). Exerts an anti-inflammatory effect during chronic inflammation and ameliorates the tissue damage associated with collagen-induced arthritis. Also shown to reduce CCR7 Protein Expression in THP1 macrophages. Shown to delay the progressive deterioration of motor performance and prevent a reduction in brain weight in murine model of Huntington′s disease. Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Packaged under inert gas

Toxicity: Standard Handling (A)

Supplied as a hydrochloride salt.

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

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