Sigma-Aldrich Sb-277011-A Dihydrochlorid

Assay

≥98% (HPLC)

Quality Level

100

Form

solid

Manufacturer/Tradename

Calbiochem^®

Storage Condition

OK to freeze
desiccated (hygroscopic)
protect from light

Color

white

Solubility

water: 100 mm

Storage Temp.

2-8°C

Inchi

1S/C28H30N4O.2ClH/c29-18-21-5-8-23-19-32(16-13-22(23)17-21)15-12-20-6-9-24(10-7-20)31-28(33)26-11-14-30-27-4-2-1-3-25(26)27;;/h1-5,8,11,14,17,20,24H,6-7,9-10,12-13,15-16,19H2,(H,31,33);2*1H/t20-,24-;;

Inchi Key

HEZIOTGUXSPDAK-ONAIBGCWSA-N

General Description

A brain-penetrant, high-affinity, and selective dopamine D3 receptor antagonist. High affinity for the hD3 receptor (pK_i= 7.95) with 100-fold selectivity over the hD2 receptor and over 66 other receptors, enzymes, and ion channels. Rat data shows that the compound is selective for the D3 receptor over certain serotonergic and cholinergic receptors at doses up to 56.0 mg/kg and strong physiological response at 32.0 mg/kg.

Biochem/Physiol Actions

Primary Target
D3

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Collins, g. T. et Al. 2005.J. Pharmacol. Exp. Ther. 314,310.
Reavill, C. et Al. 2000.J. Pharmacol. Exp. Ther. 294,1154.CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany