Sigma-Aldrich Vigabatrin

Assay

≥99% (HPLC)

Quality Level

100

Form

solid

Manufacturer/Tradename

Calbiochem^®

Storage Condition

OK to freeze
protect from light

Color

white

Solubility

H₂O: 100 mm

Storage Temp.

2-8°C

Inchi

1S/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9)

Inchi Key

PJDFLNIOAUIZSL-UHFFFAOYSA-N

General Description

A selective, irreversible inhibitor of GABA transaminase with antiepileptic properties. Covalently binds to the active site of GABA tansaminase to inactivate it in a dose-dependent manner and increases extracellular GABA levels in the brain. Rapidly absorbed following oral administration and is shown to inhibit [3H]GABA uptake across the apical membrane of Caco-2 cell monolayers in a concentration-dependent manner (IC₅₀= 2.9 mm)

Biochem/Physiol Actions

Primary Target
GABA TransaminaseReversible: no

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Abbot, E.L., et Al. 2006.Br. J. Pharmacol. 147,298.
Schmid, L., et Al. 1996.J. Pharmacol. Exp. Therap. 276,977.CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, GermanyGHS08H372P260 - P264 - P270 - P314 - P501