Sigma-Aldrich Prmt Inhibitor Vii Db867

Assay

≥98% (HPLC)

Quality Level

100

Form

solid

Potency

9 μM IC₅₀

Manufacturer/Tradename

Calbiochem^®

Storage Condition

OK to freeze
protect from light

Color

yellow

Solubility

10% acetic acid: 5 mg/mL

Storage Temp.

2-8°C

General Description

A cell-permeable biscarboxamidine derivative that acts as a selective inhibitor of protein arginine methyltransferase 1 (PRMT1; IC₅₀= 9.5 µM). Exhibits about 10-fold greater selectivity over PRMT5 (IC₅₀= 110 µM) and PRMT6 (IC₅₀= 118 µM). Shown to block BMP4-induced phosphorylation and activation of Smad1/Smad5 and asymmetric dimethylation of Arg3 on histone 4 (H4R3) in HaCaT cells transfected with PRMT1.A cell-permeable biscarboxamidine derivative that acts as a selective inhibitor of protein arginine methyltransferase 1 (PRMT1; IC₅₀= 9.5 µM). Exhibits about 10-fold greater selectivity over PRMT5 (IC₅₀= 110 µM) and PRMT6 (IC₅₀= 118 µM). Shown to block BMP4-induced phosphorylation and activation of Smad1/Smad5 and asymmetric dimethylation of Arg3 on histone 4 (H4R3) in HaCaT cells transfected with PRMT1.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/Physiol Actions

Primary Target
PRMT1Reversible: yes

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Other Notes

Xu, J., et Al, 2013.Mol. Cell. 51,1.CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany