Sigma-Aldrich Loperamide Hydrochloride

Assay

≥99% (HPLC)

Quality Level

100

Form

solid

Potency

2 nM K_i

Manufacturer/Tradename

Calbiochem^®

Storage Condition

OK to freeze
protect from light

Color

white

Solubility

DMSO: 50 mm
ethanol: 50 mm

Storage Temp.

2-8°C

Inchi

1S/C29H33ClN2O2.ClH/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32-20-17-28(34,18-21-32)23-13-15-26(30)16-14-23;/h3-16,34H,17-22H2,1-2H3;1H

General Description

A very potent and highly selective peripheral resctricted µ-opioid receptor agonist (K_i= 2 nM). Often used as an antidiarrheal, antipruritic, and antihyperalgesic agent. In addition, shown to improve defective post-receptor insulin signaling in skeletal muscle cells and enhance insulin sensitivity in rats.

Biochem/Physiol Actions

Primary Target
u opioid receptor

Warning

Toxicity: Toxic (F)

Preparation Note

Warming is required for complete solubilization in ethanol.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Cheng, K., et Al. 2013.Pharmaco. Ther. 139,334.
Di Bosco, M., et Al. 2008.Chem. Biol. Drug Des. 71,328.
DeHaven-Hudkins, D., et Al. 1999.J. Pharmacol. Exp. Ther. 289,494.
Mackerer, C., et Al. 1976.J. Pharmacol. Exp. Ther. 199,131.Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, GermanyGHS06H301P264 - P270 - P301 + P310 - P405 - P501