Sigma-Aldrich Zonisamide

Assay

≥98% (HPLC)

Quality Level

100

Form

solid

Manufacturer/Tradename

Calbiochem^®

Storage Condition

OK to freeze
protect from light

Color

white

Storage Temp.

2-8°C

Inchi

1S/C8H8N2O3S/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7/h1-4H,5H2,(H2,9,11,12)

Inchi Key

UBQNRHZMVUUOMG-UHFFFAOYSA-N

General Description

A benzisoxazole derivative that acts as an antiepileptic agent and is shown to block voltage-dependent Na(+) channels and T-type Ca(2+) channels. However, it does not serve as anticonvulsant agent in chemically induced seizures in flurothyl and pentetrazole models. Acts as an inhibitor of monoamine oxidase B (MAO-B; IC₅₀= 24.8 µM). Displays neurprotective properties.A benzisoxazole derivative that acts as an antiepileptic agent and is shown to block voltage-dependent Na(+) channels and T-type Ca(2+) channels. However, it does not serve as anticonvulsant agent in chemically induced seizures in flurothyl and pentetrazole models. Acts as an inhibitor of monoamine oxidase B (MAO-B; IC₅₀= 24.8 µM). Displays neurprotective properties.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/Physiol Actions

Primary Target
Na+ and Ca2+ channels

Warning

Toxicity: Harmful (C)

Other Notes

Sonsalla, P.K., et Al. 2010.Exp. Neurol. 221,329.
Sobieszek, g. et Al. 2003.Pol. J. Pharmacol. 55,68.CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, GermanyGHS07,GHS08H302 - H361P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405