Sigma-Aldrich Insolution Tapi-2

Quality Level

100

Assay

≥97% (HPLC)

Form

liquid

Manufacturer/Tradename

Calbiochem^®

Storage Condition

OK to freeze
protect from light

Storage Temp.

−70°C

General Description

A hydroxamate-based inhibitor of matrix metalloproteinases and TACE (TNF-α convertase; ADAM17). Inhibits the activation-dependent shedding of L-selectin from neutrophils, eosinophils, and lymphocytes as well as phenylarsine oxide (PAO)-induced shedding in neutrophils. Also blocks the shedding of several cell surface proteins such as pro-TGF-α, IL-6 receptor α-subunit, and β-amyloid precursor protein. Reported to inhibit TNF-α release and impart protection against aspirin-induced gastric mucosal injury. Acts as a weak inhibitor of angiotensin converting enzyme (IC₅₀= 18 µM).

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Physical Form

A 10 mm (1 mg/241 µL) sterile-filtered solution of TAPI-2 (Cat. No. 579052) in H₂O.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 3 months at -20°C.

Other Notes

Bennett, T.A., et Al. 2000.J. Immunol. 164,4120.
Fiorucci, S., et Al. 1998.Aliment. Pharmacol. Ther. 12,1139.
Hooper, N.M., et Al. 1997.Biochem. J. 321,265.
Parvathy, S., et Al. 1997.Biochem. J. 327,37.
Arribas, J., et Al. 1996.J. Biol. Chem. 271,11376.CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany