Sigma-Aldrich Phorbol-12-myristate-13-acetate

Sigma-Aldrich Calbiochem Phorbol-12-myristate-13-acetate, 5 mg Net Content, C36H56O8, Solid Form, Colorless, >=98 %, -20 deg C, Melting Point: 50 to 70 deg C, Phorbol-12-myristate-13-acetate - CAS 16561-29-8 - Calbiochem, PMA, TPA, PKC Activator I, TPA, PMA, PKC Activator I, 616.8 g/mol Molecular Weight, 16561-29-8 CAS Number, 698.1 deg C at 1.013,3 hPa Boiling Point, HPLC Grade. Extremely potent mouse skin tumor promoter. Activates protein kinase C (PKC) in-vivo and in vitro, even at nanomolar concentrations. Promotes the expression of iNOS in cultured hepatocytes. Activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. Inhibits apoptosis induced by the Fas antigen, but induces apoptosis in HL-60 promyelocytic leukemia cells. Most commonly used phorbol ester. Most commonly-used phorbol ester. Extremely potent mouse skin tumor promoter. Activates protein kinase C in-vivo and in-vitro, even at nM concentrations. Promotes the expression of inducible NOS in cultured hepatocytes. Activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. Inhibits apoptosis induced by the Fas antigen, but induces apoptosis in HL-60 promyelocytic leukemia cells. Its binding is reversible. Also available as a 10 mm solution in DMSO (Cat. No. 500582) - SIAL (Additional S&H Or Hazmat Fees May Apply)