Sigma-Aldrich Peroxiredoxin Inhibitor Co

Assay

≥95% (NMR)

Quality Level

100

Form

solid

Manufacturer/Tradename

Calbiochem^®

Storage Condition

OK to freeze
desiccated
protect from light

Color

yellow-brown

Solubility

DMSO: 50 mg/mL

Storage Temp.

−20°C

Inchi

1S/C10H8Br2N2O2/c11-5-9-10(6-12)14(16)8-4-2-1-3-7(8)13(9)15/h1-4H,5-6H2

Inchi Key

DQKNFTLRMZOAMG-UHFFFAOYSA-N

General Description

A cell-permeable dibromomethylquinoxaline-dioxide compound with nematicidal properties that covalently binds to the peroxidatic cysteine of peroxiredoxin II inToxoplasma gondii(TgPrxII) and irreversibly blocks its hyperperoxidation activity (IC₅₀= 23 µM). Also shown to alkylate or crosslink catalytic cysteines of wild type AcePrx-1 inAncylostoma ceylanicumand human PrxII and PrxIV to inhibit their catalytic activity with similar efficiency. Ineffective towards mitochondrial hPrxIII.A cell-permeable dibromomethylquinoxaline-dioxide compound with nematicidal properties that covalently binds to the peroxidatic cysteine of peroxiredoxin II inToxoplasma gondii(TgPrxII) and irreversibly blocks its hyperperoxidation activity (IC₅₀= 23 µM). Also shown to alkylate or crosslink catalytic cysteines of wild type AcePrx-1 inAncylostoma ceylanicumand human PrxII and PrxIV to inhibit their catalytic activity with similar efficiency. Ineffective towards mitochondrial hPrxIII.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/Physiol Actions

Cell permeable: yesPrimary Target
PeroxiredoxinReversible: noTarget IC₅₀: 23 µM for blocking TgPrxII hyperperoxidation activity

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 2 weeks at -70°C.Use only fresh DMSO for reconstitution.

Other Notes

Nguyen, J.B., et Al. 2013.Chem. Biol. 20,991.
Haraldsen, J. D., et Al. 2009.Org. Biomol. Chem. 7,3040.
Carey, K.L., et Al. 2004.Proc. Natl. Acad. Sci. USA 101,7433.CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, GermanyH413P273 - P501