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Breast carcinoma tissue, Colon, Prostate, Tonsil, Tonsilar lymphoma, Uterus, Ureter
Presentation
Chicken IgY in PBS with 5 mm sodium azide as a preservative.
Quality Level
MQ100
Applications
Application
Detect Vimentin using this Anti-Vimentin Antibody validated for use in IC.
Key Applications
Immunocytochemistry
Application Notes
Immunocytochemistry: 1:1,000-1:5,000
Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen
Recombinant vimentin.
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Chicken
Specificity
Recognizes Vimentin.
Species Reactivity
Chicken
Human
Mouse
Rat
Feline
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NM_003380.2
Entrez Gene Summary
Along with the microfilaments (actins) and microtubules (tubulins), the intermediate filaments represent a third class of well-characterized cytoskeletal elements. The subunits display a tissue-specific pattern of expression. Desmin (MIM 125660) is the subunit specific for muscle and vimentin the subunit specific for mesenchymal tissue.[supplied by OMIM]
Gene Symbol
VIM
FLJ36605
Vimentin.
vimentin
Purification Method
Unpurified
UniProt Number
P08670
UniProt Summary
FUNCTION: SwissProt: P08670 # Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. SIZE: 466 amino acids; 53652 Da SUBUNIT: Homopolymer. Component of a complex composed at least of ACTB, AP2M1, AP2A1, AP2A2, MEGF10 and VIM. Interacts with HCV core protein. TISSUE SPECIFICITY: Highly expressed in fibroblasts, some expression in T- and B-lymphocytes, and little or no expression in Burkitts lymphoma cell lines. Expressed in many hormone- independent mammary carcinoma cell lines. PTM: One of the most prominent phosphoproteins in various cells of mesenchymal origin. Phosphorylation is enhanced during cell division, at which time vimentin filaments are significantly reorganized. SIMILARITY: SwissProt: P08670 ## Belongs to the intermediate filament family.
Product Usage Statements
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
