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Millipore Active, Full Length, Recombinant Human C-Cbl. N-Terminal Gst-Tagged. For Use In Enzyme Assays. Functions As An E3 Ligase In Ubiquitination Assays. - Mill (Additional S&H or Hazmat Fees May Apply)
N-terminal cMyc and GST-tagged, recombinant human IKKγ full length, expressed by baculovirus in Sf21 insect cells.
Alternate Names
E3 ubiquitin-protein ligase CBL
Casitas B-lineage lymphoma proto-oncogene
RING finger protein 55
Signal transduction protein CBL
CBL2
RNF55
Background Information
Intracellular signals mediated by receptor tyrosine kinases play a pivotal role in morphogenesis, cell fate determination and pathogenesis. c-Cbl is a ubiquitin ligase (E3) that facilitates the regulation of these pathways, attenuating signalling through ubiquitination and subsequent protein degradation. c-Cbl contains several functional domains, including a tyrosine kinase-binding domain that associates with a number of protein tyrosine kinases in a phosphorylation-dependent manner, a catalytic RING-finger domain that interacts with E2s and is essential for E3 activity and a C-terminal proline rich domain which mediates interactions with SH3 containing proteins. Mutations in the gene for c-Cbl have been implicated in a number of human cancers, particularly acute myeloid leukaemia.
Product Information
Quality Level
MQ100
Applications
Application
Active, full length, recombinant human c-Cbl. N-terminal GST-tagged. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.
Key Applications
Enzyme Assays
Biological Information
Specific Activity
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Cascade Component
E3
Entrez Gene Number
NM_005188
Purification Method
Purified using glutathione sepharose.
Product Usage Statements
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
