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PER2 is a component of the circadian clock mechanism which is essential for generating circadian rhythms. It is a negative element in the circadian transcriptional loop by Influencing clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. PER2 negatively regulates CLOCK NPAS2-BMAL1 BMAL2-induced transactivation. This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known.
Product Information
Format
Serum
Control
C2C12 tissue lysate.
Presentation
Serum with 0.05% NaN3
Quality Level
MQ100
Applications
Application
Anti-PER2 Antibody detects level of PER2 & has been published & validated for use in WB.
Key Applications
Western Blotting
Application Notes
Western Blot Analysis: C2C12 lysate was resolved by electrophoresis, transferred to PVDF membrane and probed with anti-PER2 (1:500 dilution of this lot). Proteins were visualized using a Donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence detection system.
Biological Information
Immunogen
Synthetic peptide.
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Rabbit
Specificity
Cat. # AB2202 will recognize the N-terminus of PER2.
Species Reactivity
Mouse
Rat
Species Reactivity Note
Mouse and Rat. Reactivity with other species has not been determined.
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NP_035196
Gene Symbol
FASPS
KIAA0347
hPER2
UniProt Number
O54943
Molecular Weight
Approx. 136 kDa. Band may be observed at a much higher 200 kDa by the liver product depending on level of phophorylation and gel system used.
Product Usage Statements
Quality Assurance
Routinely evaluated by western blot on C2C12 lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt.
