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Galanin is a neuropeptide which is not a member of any known family of neuropeptides, despite repeated efforts to discover related peptides. Its actions are mediated via Gi-protein-coupled receptors (GPCR’s) and ion channels, usually producing inhibition of secretion of a transmitter or hormone in the nervous and endocrine system. In many respects, these inhibitory actions of galanin remind us of those of gamma-aminobutyric acid (GABA) and of neuropeptide Y (NPY). Galanin coexists with GABA, noradrenaline, 5-hydroxytryptamine (5-HT), and NPY in several regions of the brain. Galanin and it’s receptor are over expressed in limbic region of the brain in patients suffering from Alzheimers disease. However it is not clear whether galanin exacerbates or is a protective response to the disease.
Product Information
Format
Serum
Control
Rat Cerebellum Tissue
Presentation
Serum with 0.05% NaN3
Quality Level
MQ100
Applications
Application
Detect Galanin using this Anti-Galanin Antibody validated for use in IH(P).
Key Applications
Immunohistochemistry (Paraffin)
Biological Information
Immunogen
Synthetic Linear Peptide
Host
Rabbit
Specificity
Cat. # AB2233 recognizes Galanin
Species Reactivity
Rat
Species Reactivity Note
Rat. May react with mouse, human and Sus Scrofa based on sequence homology. Reactivity with other species has not been determined.
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NP_057057
Gene Symbol
GAL1
GALN
GLNN
GMAP
MGC40167
galanin
UniProt Number
P22466
UniProt Summary
FUNCTION: Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion. LOCATION: Secreted. SIMILARITY: Belongs to the galanin family.
Molecular Weight
13.3 kDa
Product Usage Statements
Quality Assurance
Routinely evaluated by Immunhistochemistry on rat cerebellum tissue.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Maintain at -20°C for up to 1 year from date of receipt.
