Key Specifications Table
| Key Applications |
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| Cell Based Assays |
| Description | |
|---|---|
| Catalogue Number | SCT046 |
| Description | BioTracker CyP AP Live Cell Dye |
| Overview | Alkaline Phosphatase (AP) catalyzes the hydrolysis of the phosphate group in alkaline media. AP is an essential enzyme and widely distributes in a variety of tissues such as liver, intestine, kidney, bone, and placenta. Abnormal AP levels have been shown in numerous cancers, bone disease and liver dysfunction. AP is also expressed by pluripotent stem cells such as ES and IPS cells. The BioTracker CyP AP dye is a live cell near-infrared (NIR) fluorescent imaging probe for alkaline phosphatase. With its long emission wavelength, the probe is suitable for monitoring AP levels in both in vivo and in vitro tissues and cells. The probe possesses deep tissue penetration, less damage to the biological samples, and lower interference from the background fluorescence compared to other AP probes. Spectral Properties Absorbance: 690nm Emission: 738nm References Nie SX et al. Facile and Sensitive Near-Infrared Fluorescence Probe for the Detection of Endogenous Alkaline Phosphatase Activity In Vivo. Anal Chem. 2017 Jun 20;89(12):6854-6860. |
| Alternate Names |
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| Product Information | |
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| Detection method | Fluorescence |
| Presentation | Lyophilized |
| Applications | |
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| Application | Live cell imaging dye for alkaline phosphatase (AP) for cancer and stem cell applications. |
| Key Applications |
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| Application Notes | Live cell fluorescent imaging |
| Product Usage Statements | |
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| Quality Assurance | Purity: ≥ 98% confirmed by HNMR, LC-MS and HPLC and elemental analysis Molar Mass: 528.55 g/mol |
| Usage Statement |
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| Storage and Shipping Information | |
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| Storage Conditions | Store BioTracker CyP AP Live Cell Dye at -20°C, desiccate and protect from light Note: Centrifuge vial briefly to collect contents at bottom of vial before opening. |
| Packaging Information | |
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| Material Size | 1 mg |