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| Description | |
|---|---|
| Catalogue Number | AG221 |
| Brand Family | Chemicon® |
| Trade Name |
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| Description | Dopamine D2 Receptor, control peptide for AB5084P |
| Overview | 28 amino acid peptide sequence from the human D2 R within the cytoplasmic loop #3. The 28 amino acid sequence is shared by both the long and short form. |
| Product Information | |
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| Presentation | Liquid in PBS, pH 7.5. No preservative. |
| Quality Level | MQ100 |
| Applications | |
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| Key Applications |
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| Application Notes | For use in blocking the staining of AB5084P. Optimal working dilution must be determined by the end user. |
| Biological Information | |
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| Concentration | 1 mg/mL |
| Entrez Gene Number |
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| Entrez Gene Summary | This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. |
| Gene Symbol |
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| UniProt Number |
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| UniProt Summary | FUNCTION: SwissProt: P14416 # This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. SIZE: 443 amino acids; 50619 Da SUBUNIT: Interacts with GPRASP1, neurabin-2 and CLIC6 (By similarity). Interacts with CADPS and CADPS2. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. DISEASE: SwissProt: P14416 # It has been suggested that DRD2 is involved in psychiatric disorders; especially in schizophrenia. & Defects in DRD2 are associated with myoclonus dystonia (MD) [MIM:159900]; also known as myoclonic dystonia, alcohol- responsive dystonia and dystonia-11 (DYT11). MD is a movement disorder characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable. SIMILARITY: SwissProt: P14416 ## Belongs to the G-protein coupled receptor 1 family. |
| Product Usage Statements | |
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| Usage Statement |
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| Storage and Shipping Information | |
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| Storage Conditions | Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. |
| Packaging Information | |
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| Material Size | 100 µg |