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Millipore Anti-Homeodomain-Only Protein Antibody, Clone 15c1.1
Millipore Anti-Homeodomain-Only Protein Antibody, Clone 15c1.1
List Price$557.76Your Price$557.76
Millipore This Anti-Homeodomain-Only Protein Antibody, Clone 15c1.1 Is Validated For Use In Western Blotting For The Detection Of Homeodomain-Only Protein. - Mill (Additional S&H or Hazmat Fees May Apply)
Anti-Homeodomain-only Protein Antibody, clone 15C1.1
Alternate Names
Lung cancer-associated Y protein
Homeodomain-only Protein
Not expressed in choriocarcinoma protein 1
Odd homeobox protein 1
Background Information
Homeodomain-only protein (UniProt Q9BPY8; also known as Lung cancer-associated Y protein, Not expressed in choriocarcinoma clone 1, Not expressed in choriocarcinoma protein 1, Odd homeobox 1 protein, Odd homeobox protein 1) is encoded by the HOPX (also known as CAMEO, HOD, HOP, LAGY, NECC1, OB1, SMAP31, TOTO) gene (Gene ID 84525) in human. Human and mouse HOPX proteins share 92% identity, they contain homeobox-like domain but lack sequence motif required for DNA binding. HOPX is highly expressed in the developing heart, where its expression is dependent on the cardiac-restricted homeobox protein, Nkx2.5. HOPX physically interacts with serum responsive factor (SRF) and inhibits SRF-dependent transcription by inhibiting SRF binding to DNA and by recruiting histone deacetylase (HDAC) activity. HOPX is reported to play a critical role in the differentiation of various cells such as myoblasts, trophoblasts, keratinocytes, T cells, and lung alveolar cells. HOPX was initially reported as a differentiation marker and is expressed in various normal tissues, and HOPX expression is markedly suppressed in a subset of cancers.
Product Information
Format
Purified
Presentation
Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
This Anti-Homeodomain-only Protein Antibody, clone 15C1.1 is validated for use in Western Blotting for the detection of Homeodomain-only Protein.
Key Applications
Western Blotting
Biological Information
Immunogen
GST-tagged recombinant protein corresponding to human Homeodomain-only Protein.
Clone
15C1.1
Concentration
Please refer to lot specific datasheet.
Host
Mouse
Specificity
Expected to react with spliced isoforms 1, 3, and 4. Reactivity toward isoform 2 has not been determined.
Isotype
IgG2bκ
Species Reactivity
Mouse
Species Reactivity Note
Mouse. Predicted to react with human based on 100% sequence homology.
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_001138931
Gene Symbol
HOPX
HOD
HOP
LAGY
NECC1
OB1
Purification Method
Protein G Purified
UniProt Number
Q9BPY8
Molecular Weight
~10 kDa observed. Uncharacterized band(s) may appear in some lysates.
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in mouse lung tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected Homeodomain-only Protein in 10 µg of mouse lung tissue lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
