Name: Millipore Anti-Von Willebrand Factor Antibody
SKU: MILL-AB7356-25UG
Price: 202.02 USD

Millipore Anti-Von Willebrand Factor Antibody

List Price $202.02 Your Price $202.02

Millipore This Anti-Von Willebrand Factor Antibody Is Validated For Use In Elisa, Immunohistochemistry (Ihc) For The Detection Of Von Willebrand Factor. - Mill (Additional S&H or Hazmat Fees May Apply)

NETA PART: MILL-AB7356-25UG

MFG.PART: AB7356-25UG

UNSPSC: 12350000

Manufacturer: Millipore

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Description
Catalogue Number	AB7356-25UG
Brand Family	Chemicon®
Trade Name	Chemicon
Description	Rb X vWF
Alternate Names	Factor VIII Related Antigen
Background Information	von Willebrand Factor (vWF) is synthesized by endothelial cells, causing adhesion of platelets to injured vessel walls and functions as a carrier and stabilizer for coagulation of Factor VIII. It is one of the most widely used endothelial cell markers for studying angiogenesis / neovascularization. Millipores von Willebrand Factor antibody reacts specifically with the endothelial cells of blood vessels and is a useful marker for the identification of endothelial lineage in tumors.

Product Information
Format	Purified
Control	POSITIVE CONTROL: Human tonsils, Mouse and rat brain.
Presentation	Purified rabbit immunoglobulin in buffer containing 0.02 M PBS pH 7.6, 0.25 M NaCl with 0.1% sodium azide.
Quality Level	MQ100

Applications
Application	This Anti-von Willebrand Factor Antibody is validated for use in ELISA, Immunohistochemistry (IHC) for the detection of von Willebrand Factor.
Key Applications	ELISA Immunohistochemistry (Paraffin)
Application Notes	ELISA: A 1:1000-1:5000 dilution of a previous lot was used in direct ELISA. Optimal working dilutions must be determined by the end user.

Biological Information
Immunogen	Human von Willebrand Factor purified from plasma.
Concentration	Please refer to lot specific datasheet.
Host	Rabbit
Specificity	AB7356 is specific for vWF by ELISA against the human protein and by immunohistochemistry. The antibody is reactive in paraffin embedded tissues on human, rat, and mouse. Other species not tested. Antibody has not been evaluated by western blot analysis for reactivity to vWF.
Species Reactivity	Human Mouse Rat
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NM_000552.3
Entrez Gene Summary	The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrands disease. An unprocessed pseudogene has been found on chromosome 22.
Gene Symbol	VWF F8VWF F8 vWF VWD
Purification Method	Protein A Purfied
UniProt Number	P04275
UniProt Summary	FUNCTION: SwissProt: P04275 # Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. SIZE: 2813 amino acids; 309299 Da SUBUNIT: Multimeric. Interacts with F8. SUBCELLULAR LOCATION: Secreted. Note=Localized to storage granules. TISSUE SPECIFICITY: Plasma. DOMAIN: SwissProt: P04275 The von Willebrand antigen 2 is required for multimerization of VWF and for its targeting to storage granules. PTM: All cysteine residues are involved in intrachain or interchain disulfide bonds. DISEASE: SwissProt: P04275 # Defects in VWF are associated with various forms of von Willebrand disease (VWD) [MIM:193400, 277480]. VWD is characterized by frequent bleeding (gingival, minor skin quantitative lacerations, menorrhagia, etc.). Type I VWD is associated with a deficiency of VWF; type II by normal to decreased plasma level of VWF; type III by a virtual absence of VWF. There are subtypes (A to H) of type II VWD; for example: type IIA is characterized by the absence of VWF high molecular weight multimers in plasma. SIMILARITY: Contains 1 CTCK (C-terminal cystine knot-like) domain. & Contains 4 TIL (trypsin inhibitory-like) domains. & Contains 3 VWFA domains. & Contains 3 VWFC domains. & Contains 4 VWFD domains.
Molecular Weight	250 kDa

Product Usage Statements
Quality Assurance	Immunohistochemistry(paraffin): Representative images from a previous lot. Rabbit anti-vWF (AB7356) staining of Human Cerebral Cortex. Tissue pretreated with Citrate Buffer, ph 6.0, anti-vWF at 20 μg/mL, IHC-Select Detection with HRP-DAB.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8ºC from date of receipt.

Packaging Information
Material Size	25 μg

More Information

SKU

MILL-AB7356-25UG

Featured

Supplier Part Number

AB7356-25UG

UNSPSC

12350000

Manufacturer

Millipore

ProductLine

MILL

Qty

MinOrderQty

Weight

10.000000

Lead Time

Hazardous

Energy Star

Green

ACT Ecolabel

Controlled

NETA PART NO.	Quantity

Millipore Anti-Von Willebrand Factor Antibody

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