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Millipore Anti-Olig-2 Antibody, Alexa Fluor® 488 Conjugate Is An Antibody Against Olig-2 For Use In Immunofluorescence. - Mill (Additional S&H or Hazmat Fees May Apply)
Oligodendrocyte transcription factor 2 (UniProt Q9EQW6; also known as bHLHe19, Olig-2, Oligo2, RACK17, RK17) is encoded by the Olig2 (also known as Bhlhb1) gene (Gene ID 50913) in murine species. Olig2 is a basic helix-loop-helix (bHLH) transcription factor expressed in a spinal cord ventricular zone domain where it mediates the sequential generation of motoneurons and oligodendrocytes during embryogenesis. Olig2 also functions as an anti-neurogenic factor in pMN progenitors at early time points to sustain the cycling progenitor pool. The anti-neurogenicity of Olig2 is also responsible for its role in tumorigenesis, especially in brain tumors and leukemia. Due to its expression in glioblastoma and other diffuse gliomas, Olig2 is a useful diagnostic marker of these brain tumors.
Product Information
Format
AlexaFluor®488
Presentation
Purified rabbit polyclonal antibody conjugate in PBS with 15 mg/mL BSA and 0.1 % sodium azide.
Quality Level
MQ100
Applications
Application
Anti-Olig-2 Antibody, Alexa Fluor® 488 Conjugate is an antibody against Olig-2 for use in Immunofluorescence.
Key Applications
Immunofluorescence
Application Notes
The unconjugated antibody (Cat. No. AB9610) is shown to be suitable also for Western blotting, immunocytochemistry, immunohistochemistry, and immunoprecipitation applications.
Biological Information
Immunogen
Recombinant mouse Olig-2.
Concentration
Please refer to lot specific datasheet.
Host
Rabbit
Specificity
The unconjugated antibody (Cat. No. AB9610) recognizes the ~32 kDa Olig-2 protein by Western blotting.
Species Reactivity
Human
Mouse
Rat
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NM_016967.2
Gene Symbol
Olig2
Bhlhb1
Purification Method
Ammonium Sulfate
UniProt Number
Q9EQW6
Molecular Weight
~32 kDa observed.
Product Usage Statements
Quality Assurance
Evaluated by Immunofluorescence in mouse brain tissue.
Immunofluorescence Analysis: A 1:50-100 dilution of this antibody detected Olig-2 in mouse brain tissue sections.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
