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Millipore This Anti-Foxl1 Antibody Is Validated For Use In Western Blotting, Immunohistochemistry (Paraffin) For The Detection Of Foxl1. - Mill (Additional S&H or Hazmat Fees May Apply)
Forkhead box protein L1 (UniProt Q12952; also known as Forkhead-like 11, Forkhead-related protein FKHL11, Forkhead-related transcription factor 7, FREAC-7) is encoded by the FOXL1 (also known as FKHL11, FREAC7) gene (Gene ID 2300) in human. FOXL1 protein belongs to the forehead box (Fox) family of transcription factors characterized by a common DNA-binding domain (the forkhead box). FOXL1 is involved in regulating the proliferation of gastrointestinal epithelial cells. Loss of Foxl1 leads to distorted architecture of the stomach and small intestine in mice due to a markedly increased epithelial proliferation. Foxl1 knockout is correlated with an enhanced Wnt/β-catenin pathway activation as evidenced by increased β-catenin nuclear localization. FOXL1 expression is down-regulated in the majority of human clear cell renal cell carcinoma (ccRCC), at both mRNA and protein levels. FOXL1 expression inversely correlates with the aggressive phenotype of ccRCC and the survival outcome of patients.
Product Information
Format
Affinity Purified
Presentation
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
This Anti-FOXL1 Antibody is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of FOXL1.
Key Applications
Western Blotting
Immunohistochemistry (Paraffin)
Application Notes
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected FOXL1 in human breast cancer tissue.
Biological Information
Immunogen
KLH-conjugated linear peptide corresponding to human FOXL1.
Concentration
Please refer to lot specific datasheet.
Host
Rabbit
Species Reactivity
Human
Species Reactivity Note
Human. Predicted to react with Horse, Porcine, Bovine, Feline, Sheep based on 100% sequence homology.
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NP_005241
Gene Symbol
FOXL1
FKHL11
FREAC7
Purification Method
Affinity Purfied
UniProt Number
Q12952
Molecular Weight
~36 kDa observed. Uncharacterized band(s) may appear in some lysates.
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in human colon tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected FOXL1 in 10 µg of human colon tissue lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
