Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H | IH(P) | Rb | Affinity Purified | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | ABN1456 |
| Description | Anti-IAPP |
| Alternate Names |
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| Background Information | Islet amyloid polypeptide (UniProt: P10997; also known as Amylin; Diabetes-associated peptide; DAP; Insulinoma amyloid peptide, IAPP) is encoded by the IAPP gene (Gene ID: 3375) in human. IAPP is a secreted peptide that is degraded by insulin degrading enzyme (IDE). IAPP is a major constituent of amyloid deposits in pancreatic islets, characteristic histopathology for type 2 diabetes. The mature IAPP is largely unstructured in the absence of a cognate ligand, and has a strong tendency to form fibrillar aggregates. In diabetic islets, water-soluble IAPP is shown to disappear in beta-cell granules and is transformed to water-insoluble amyloid deposits that can initiate beta cell necrosis. Oligomers of human IAPP can form toxic oligomers and induce apoptosis in cultured pancreatic cells. IAPP is shown to selectively inhibit insulin-stimulated glucose utilization and glycogen deposition in muscle, but does not affect adipocyte glucose metabolism. (Ref.: Bram, Y., et al. (2014). Scientific Reports 4, Article number: 4267; Tomita, T. (2012). Islets. 4(3): 223 232). |
| Product Information | |
|---|---|
| Format | Affinity Purified |
| Presentation | Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Anti-IAPP, Cat. No. ABN1456, is a highly specific rabbit polyclonal antibody that targets Islet amyloid polypeptide and has been tested in Immunohistochemistry (Paraffin). |
| Key Applications |
|
| Biological Information | |
|---|---|
| Immunogen | A KLH-conjugated linear peptide from an internal region of human islet amyloid polypeptide. |
| Concentration | Please refer to lot specific datasheet. |
| Host | Rabbit |
| Specificity | This polyclonal antibody detects IAPP in human pancreatic tissue. |
| Species Reactivity |
|
| Species Reactivity Note | Human. |
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
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| Gene Symbol |
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| Purification Method | Affinity Purified |
| UniProt Number |
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| Molecular Weight | 9.8 kDa calculated |
| Product Usage Statements | |
|---|---|
| Quality Assurance | Evaluated by Immunohistochemistry in human pancreas tissue. Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected IAPP in human pancreas tissue. |
| Usage Statement |
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| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Stable for 1 year at 2-8°C from date of receipt. |
| Packaging Information | |
|---|---|
| Material Size | 100 µL |