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Millipore Anti-Iapp, Cat. No. Abn1456, Is A Highly Specific Rabbit Polyclonal Antibody That Targets Islet Amyloid Polypeptide And Has Been Tested In Immunohistochemistry (Paraffin). - Mill (Additional S&H or Hazmat Fees May Apply)
Islet amyloid polypeptide (UniProt: P10997; also known as Amylin; Diabetes-associated peptide; DAP; Insulinoma amyloid peptide, IAPP) is encoded by the IAPP gene (Gene ID: 3375) in human. IAPP is a secreted peptide that is degraded by insulin degrading enzyme (IDE). IAPP is a major constituent of amyloid deposits in pancreatic islets, characteristic histopathology for type 2 diabetes. The mature IAPP is largely unstructured in the absence of a cognate ligand, and has a strong tendency to form fibrillar aggregates. In diabetic islets, water-soluble IAPP is shown to disappear in beta-cell granules and is transformed to water-insoluble amyloid deposits that can initiate beta cell necrosis. Oligomers of human IAPP can form toxic oligomers and induce apoptosis in cultured pancreatic cells. IAPP is shown to selectively inhibit insulin-stimulated glucose utilization and glycogen deposition in muscle, but does not affect adipocyte glucose metabolism. (Ref.: Bram, Y., et al. (2014). Scientific Reports 4, Article number: 4267; Tomita, T. (2012). Islets. 4(3): 223 232).
Product Information
Format
Affinity Purified
Presentation
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-IAPP, Cat. No. ABN1456, is a highly specific rabbit polyclonal antibody that targets Islet amyloid polypeptide and has been tested in Immunohistochemistry (Paraffin).
Key Applications
Immunohistochemistry (Paraffin)
Biological Information
Immunogen
A KLH-conjugated linear peptide from an internal region of human islet amyloid polypeptide.
Concentration
Please refer to lot specific datasheet.
Host
Rabbit
Specificity
This polyclonal antibody detects IAPP in human pancreatic tissue.
Species Reactivity
Human
Species Reactivity Note
Human.
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NP_000406
Gene Symbol
IAPP
Purification Method
Affinity Purified
UniProt Number
P10997
Molecular Weight
9.8 kDa calculated
Product Usage Statements
Quality Assurance
Evaluated by Immunohistochemistry in human pancreas tissue.
Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected IAPP in human pancreas tissue.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
