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Millipore Detect Her4 Using This Rabbit Polyclonal Anti-Phospho-Her4 Antibody, Cat. No. Abs796, Validated For Use In Western Blotting, Immunohistochemistry, And Immunocytochemistry. - Mill (Additional S&H or Hazmat Fees May Apply)
Receptor tyrosine-protein kinase erbB-4, also known as, Proto-oncogene-like protein c-ErbB-4 (4ICD or E4ICD), and encoded by the gene names Erbb4 or Tyro-2, plays an essential role as cell surface receptor for neuregulins. ERBB4 regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. ERBB4 is preferentially expressed in the developing nervous system. It exhibits distinct and highly regionalized patterns of expression in the adult brain, where it is mainly found in the reticular nucleus of the thalamus.
Product Information
Format
Affinity Purified
Presentation
Purified rabbit polyclonal in buffer containing PBS with 0.09% (w/v) sodium azide.
Quality Level
MQ100
Applications
Application
Detect HER4 using this rabbit polyclonal Anti-phospho-HER4 Antibody, Cat. No. ABS796, validated for use in Western Blotting, Immunohistochemistry, and Immunocytochemistry.
Key Applications
Western Blotting
Immunohistochemistry
Immunocytochemistry
Application Notes
Immunohistochemistry Analysis (IHC): A 1:10-50 dilution from a representative lot detected HER4 in human cancer tissue.
Immunocytochemistry Analysis (ICC): A 1:10-50 dilution from a representative lot detected HER4 in MCF-7 cells.
Biological Information
Immunogen
KLH-conjugated synthetic peptide corresponding to human PGK1 phosphorylated at Tyr1162.
Epitope
Phosphorylated Tyr1162
Concentration
Please refer to lot specific datasheet.
Host
Rabbit
Species Reactivity
Human
Antibody Type
Polyclonal Antibody
Gene Symbol
ERBB4
Modifications
Phosphorylation
Purification Method
Affinity
UniProt Number
Q15303
Molecular Weight
~160 kDa observed. Uncharacterized bands may be observed in some lysate(s).
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in untreated and EGF treated A431 cell lysates.
Western Blotting Analysis (WB): A 1:1000 dilution of this antibody detected HER4 in untreated and EGF treated A431 cell lysates.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Stable for 1 year at 2-8°C from date of receipt. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
