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Millipore This Rabbit Polyclonal Anti-Liprin Alpha 1, Cat. No. Abt268 Detects Liprin Alpha 1 In Human Cells. It Has Been Tested For Use In Western Blotting. - Mill (Additional S&H or Hazmat Fees May Apply)
Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1
PTPRF-interacting protein alpha-1
Background Information
Liprin-alpha-1 (UniProt: Q13136; also known as LAR-interacting protein 1, LIP-1, Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1, PTPRF-interacting protein alpha-1) is encoded by the PPFIA1 (also known as LIP1) gene (Gene ID: 8500) in human. Liprin-alpha-1 is a member of the LAR (leukocyte common antigen-related) protein tyrosine phosphatase-interacting protein (liprin) family. It is a cytoplasmic protein that regulates the disassembly of focal adhesions. It forms homodimers and heterodimers with Liprin-alpha and Liprin-beta. Liprins contain an N-terminal coiled-coil domain and a C-terminal liprin homology (LH) region comprised of three sterile alpha motif (SAM) domains. The N-terminal region acts as a binding region for several synaptic proteins. SAM domain are known to bind to both protein kinases and phosphatases. In mast cells, liprin-alpha-1 facilitates exocytosis and cell spreading.
Product Information
Format
Affinity Purified
Presentation
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
This rabbit polyclonal Anti-Liprin Alpha 1, Cat. No. ABT268 detects Liprin alpha 1 in human cells. It has been tested for use in Western Blotting.
Key Applications
Western Blotting
Biological Information
Immunogen
GST-tagged recombinant fragment of 179 amino acids from the internal region of human Liprin Alpha 1.
Concentration
Please refer to lot specific datasheet.
Host
Rabbit
Specificity
This polyclonal antibody detects Liprin Alpha 1 in human. It targets an epitope within 179 amino acids from the internal region of isoform 1 and 2.
Species Reactivity
Human
Species Reactivity Note
Human.
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NP_003617
NP_803172
Gene Symbol
PPFIA1
LIP1
Purification Method
Affinity Purified
UniProt Number
Q13136
Molecular Weight
~160 kDa observed; 135.78 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in HeLa cell lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Liprin Alpha 1 in 10 µg of HeLa cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
