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Millipore Anti-A2b5 Antibody, Clone A2b5-105, Alexa Fluor® 647 Conjugate Cat. No. Mab312-Af647, Is A Highly Specific Mouse Monoclonal Antibody That Targets A2b5 And Has Been Tested - Mill (Additional S&H or Hazmat Fees May Apply)
A2B5 (also known as F12A2B5) is a cell surface ganglioside expressed on developing thymic epithelial cells, oligodendrocyte progenitors, and neuroendocrine cells. It is highly expressed in embryonic and neonatal tissue, but in the adult mammalian brain its expression is restricted mainly to areas that retain neurogenic potential, such as the subventricular zone (SVZ). Hence, A2B5 is considered as a marker for immature glial-committed precursors, which are permanently generated in the SVZ. Its expression is also considered as a marker for various cancers, including astrocytoma, glioma, pancreatic islet tumors, and squamous cell carcinoma. Explants from A2B5+ tumor cells display a typical progenitor morphology and clearly indicate their immature state. Tumors expressing A2B5 antigen exhibit higher rates of recurrence.
Product Information
Format
AlexaFluor®647
Presentation
Purified mouse IgM Alexa Fluor® 647 conjugate in PBS with 1.5% BSA and 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-A2B5 Antibody, clone A2B5-105, Alexa Fluor® 647 Conjugate Cat. No. MAB312-AF647, is a highly specific mouse monoclonal antibody that targets A2B5 and has been tested in Immunocytochemistry and Flow Cytometry.
Key Applications
Flow Cytometry
Immunocytochemistry
Application Notes
Flow Cytometry Analysis: 1:400 dilution from a representative lot immunostained the surface of PC12 cells.
The unconjugated antibody (Cat. No. MAB312) is also available for flow cytometry, immunocytochemistry, immunofluorescence, and immunohistochemistry applications.
Biological Information
Immunogen
Embryonic chicken retinal cells.
Clone
A2B5-105
Concentration
Please refer to lot specific datasheet.
Host
Mouse
Specificity
This monoclonal antibody detects A2B5 in mammalian cells.
Isotype
IgM
Species Reactivity
Mammals
Species Reactivity Note
Mammals.
Antibody Type
Monoclonal Antibody
Purification Method
Ammonium sulfate.
UniProt Number
Not Applicable
Product Usage Statements
Quality Assurance
Evaluated by immunocytochemistry of PC12 cells.
Immunocytochemistry Analysis: A 1:100 Dilution of this antibody immunostained the surface of PC12 cells.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
