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Millipore Anti-Tyrosine Hydroxylase Antibody, Clone Lnc1, Alexa Fluor® 488 Conjugate Is An Antibody Against Tyrosine Hydroxylase For Use In Immunocytochemistry. - Mill (Additional S&H or Hazmat Fees May Apply)
Tyrosine 3-monooxygenase (EC 1.14.16.2; UniProt P07101; also known as Dystonia 14, TH, Tyrosine 3-hydroxylase) is encoded by the TH (also known as DYT14, DYT5b, TYH) gene (Gene ID 7054) in human. Tyrosine hydroxylase plays an important role in the physiology of adrenergic neurons. It is the first and rate-limiting enzyme involved in the biosynthesis of the catecholamines Dopamine and Norepinephrine from tyrosine. TH is, therefore, a useful marker for dopaminergic and noradrenergic neurons. TH enzymatic activity requires ferrous ions as cofactors and is believed to be regulated by phosphorylation. Six isoforms of human TH exist as a result of alternative splicing (UniProt P07101-1 through P07101-6).
Product Information
Format
AlexaFluor®488
Presentation
Purified mouse antibody conjugate in PBS with 15 mg/mL BSA and 0.1 % sodium azide.
Quality Level
MQ100
Applications
Application
Anti-Tyrosine Hydroxylase Antibody, clone LNC1, Alexa Fluor® 488 Conjugate is an antibody against Tyrosine Hydroxylase for use in Immunocytochemistry.
Key Applications
Immunocytochemistry
Application Notes
The unconjugated antibody (Cat. No. MAB318) is shown to be suitable also for Western blotting, immunohistochemistry, and immunoprecipitation applications.
Biological Information
Immunogen
Tyrosine Hydroxylase purified from PC12 cells.
Epitope
On the outside of the regulatory N-terminus of tyrosine hydroxylase.
Clone
LNC1
Concentration
Please refer to lot specific datasheet.
Host
Mouse
Specificity
Recognizes an epitope on the outside of the regulatory N-terminus of tyrosine hydroxylase. Does not react with dopamine-beta-hydroxylase, phenylalanine hydroxylase, trytophan hydroxylase, dehydropteridine reductase, sepiapterin reductase, or phenethanolamine-N-methyl transferase (PNMT) by Western blotting using the unconjugated antibody (Cat. No. MAB318).
Isotype
IgG1κ
Species Reactivity
Zebrafish
Chicken
Frog
Human
Mouse
Rat
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NM_000360.3
Gene Symbol
TH
TYH
Purification Method
Protein A Purfied
UniProt Number
P07101
Molecular Weight
~59-63 kDa observed
Product Usage Statements
Quality Assurance
Evaluated by Immunocytochemistry in rat cortical neurons.
Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected Tyrosine Hydroxylase in rat cortical neurons.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
