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Millipore Detect Tnfsf13 Using This Armenian Hamster Monoclonal Anti-Tnfsf13 (April) Antibody, Clone A3d8, Cat. No. Mabc1031, Validated For Use In Flow Cytometry. - Mill (Additional S&H or Hazmat Fees May Apply)
Tumor necrosis factor ligand superfamily member 13 (UniProt: Q9D777; also known as A proliferation-inducing ligand; APRIL; CD256) is encoded by the Tnfsf13 (also known as APRIL) gene (Gene ID: 69583) in mouse. APRIL is a secreted cytokine of the tumor necrosis family and is present in T cells, B cells, dendritic cells, monocytes, and macrophages. April exists as a functional homotrimer, but can form functional heterotrimers with B cell activating factor (BAFF). APRIL stimulates T and B cell proliferation and it exerts T and B cell regulatory effects by binding to TNFRSF17 (BCMA) and TNFRSF13B (TACI) receptors. It is also involved in monocyte/macrophage-mediated immunological processes. It also plays a role in the regulation of tumor cell growth and can induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. APRIL can serve as as a potential biomarker and its serum levels are shown to be elevated for certain cancers and expression levels elevated in cancer tissues.
Product Information
Format
Purified
Presentation
Purified armenian hamster monoclonal antibody IgG in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Detect TNFSF13 using this armenian hamster monoclonal Anti-TNFSF13 (APRIL) antibody, clone A3D8, Cat. No. MABC1031, validated for use in Flow Cytometry.
Key Applications
Flow Cytometry
Application Notes
Flow Cytometry Analysis: 1 µg of this antibody from a representative lot detected TNFSF13 in one million RAW264.7 cells.
Biological Information
Immunogen
A full length recombinant fusion protein of murine maltose binding protein (MBP) and soluble APRIL.
Clone
A3D8
Concentration
Please refer to lot specific datasheet.
Host
Armenian Hamster
Specificity
Clone A3D8 detects TNFSF13/APRIL in human peripheral blood mononuclear cells (PBMC).
Isotype
IgG
Species Reactivity
Mouse
Human
Species Reactivity Note
Human, Mouse.
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_076006
Gene Symbol
Tnfsf13
APRIL
Purification Method
Protein G purified
UniProt Number
Q9D777
Molecular Weight
26.89 kDa calculated.
Product Usage Statements
Quality Assurance
Evaluated by Flow Cytometry in human PBMC cells.
Flow Cytometry Analysis: 1 µg of this antibody detected TNFSF13 in human PBMC cells.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
