The store will not work correctly when cookies are disabled.
We use cookies to make your experience better.To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
NETA ALERT: Due to inclement weather our offices are closed today, Monday Feb. 23. We will not be shipping orders.
Millipore Detect Pthlh Using This Mouse Monoclonal Anti-Pthrp Antibody, Clone 4c4.1, Cat. No. Mabc532, Validated For Use In Western Blotting. - Mill (Additional S&H or Hazmat Fees May Apply)
Parathyroid hormone-related protein (UniProt P12272; also known as Parathyroid hormone-like related protein, Parathyroid hormone-like hormone preproprotein, PLP, PTH-related protein, PTH-rP, PTHrP) is encoded by the PTHLH (also known as BDE2, HHM, PTHR, PTHRP) gene (Entrez Gene ID 5744) in human. Parathyroid hormone-related protein is initially translated as a 177 amino acid preproprotein with an N-terminal signal sequence (aa 1-24) and a propeptide sequence (aa 25-34), which are later removed to yield the mature protein. The mature protein is further cleaved to produce PTHrP[1-34] (aa 37-70), PTHrP[1-36] (aa 37-72), PTHrP[38-94] (aa 74-130), and PTHrP[107-139] (aa 143-175; also known as Osteostatin). PTHrP is produced in a wide variety of tissues, where it acts as a paracrine or autocrine factor to regulate cellular and organ growth, development, migration, differentiation, calcium transport, survival and apoptosis.
Product Information
Format
Purified
Presentation
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Detect PTHLH using this mouse monoclonal Anti-PTHrP Antibody, clone 4C4.1, Cat. No. MABC532, validated for use in Western Blotting.
Key Applications
Western Blotting
Biological Information
Immunogen
GST-tagged recombinant human PTHrP lacking signal and propeptide sequence.
Clone
4C4.1
Concentration
Please refer to lot specific datasheet.
Host
Mouse
Isotype
IgG1κ
Species Reactivity
Human
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_945316
Gene Symbol
PTHRP
PTHLH
Purification Method
Protein G Purified
UniProt Number
P12272
Molecular Weight
~16/6 kDa observed. Uncharacterized band(s) may appear in some lysates.
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in MCF-7 cell lysate.
Western Blotting Analysis: 2.0 µg/mL of this antibody detected PTHrP in 10 µg of MCF-7 cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
