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Millipore Detect Bcl-2 Using This Rat Monoclonal Anti-Bcl-2 Antibody, Clone 1d7.2, Cat. No. Mabc573, Validated For Use In Western Blotting. - Mill (Additional S&H or Hazmat Fees May Apply)
Apoptosis regulator Bcl-2 (UniProt P10417; also known as B-cell leukemia/lymphoma 2) is encoded by the Bcl2 (also known as Bcl-2, AW986256, C430015F12Rik, D630044D05Rik, D830018M01Rik) gene (Gene ID 12043) in murine species. Bcl-2 is an anti-apoptotic and the founding member of the Bcl-2 family of proteins that paly either a pro- or anti-apoptotic role in cell death signaling. BCL-2 family members are related by regions of sequence and structural homology. The pro-survival members contain four BCL-2 homology regions (BH1–BH4), whereas the BH3-only members contain only the BH3 amphipathic helix, which mediates their interaction with the groove of multi-domain BCL-2 family members. Human BCL2 gene mutatons are well known causes of many cancers, including melanoma, breast, prostate, chronic lymphocytic leukemia, and lung cancer.
Product Information
Format
Purified
Presentation
Purified rat monoclonal IgG2aκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mm NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Detect Bcl-2 using this rat Monoclonal Anti-Bcl-2 Antibody, clone 1D7.2, Cat. No. MABC573, validated for use in Western Blotting.
Key Applications
Western Blotting
Biological Information
Immunogen
GST-tagged recombinant protein corresponding to the N-terminal of mouse Bcl-2.
Epitope
N-terminal half
Clone
1D7.2
Concentration
Please refer to lot specific datasheet.
Host
Rat
Specificity
Expected to react with both spliced isoforms of murine Bcl-2.
Evaluated by Western Blotting in mouse myoblast C2C12 cell lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected Bcl-2 in 10 µg of mouse myoblast C2C12 cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
