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Millipore This Anti-Serpinb5 Antibody, Clone 5c6.2 Is Validated For Use In Western Blotting, Immunohistochemistry (Paraffin) For The Detection Of Serpinb5. - Mill (Additional S&H or Hazmat Fees May Apply)
Serpin B5 (UniProt P36952; also known as Maspin, Peptidase inhibitor 5, PI-5) is encoded by the SERPINB5 (also known as PI5) gene (Gene ID 5268) in human. Serpin B5/Maspin is an evolutionarily conserved serine protease inhibitor that induces apoptosis and inhibits the motility of breast cancer cells. DNA hypermethylation and histone deacetylation lead to silencing of the SERPINB5 gene in human breast cancer.
Product Information
Format
Purified
Presentation
Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
This Anti-SERPINB5 Antibody, clone 5C6.2 is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of SERPINB5.
Key Applications
Western Blotting
Immunohistochemistry (Paraffin)
Application Notes
Western Blotting Analysis: 1.0 µg/mL from a representative lot detected SERPINB5 in 10 µg of HT-1080 and HT-29 cell lysates. Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected SERPINB5 in human breast tissue.
Biological Information
Immunogen
GST-tagged recombinant protein corresponding to the C-terminal of human SERPINB5.
Epitope
C-terminal half
Clone
5C6.2
Concentration
Please refer to lot specific datasheet.
Host
Mouse
Specificity
Does not detect spliced isoform 2 (UniProt P36952-2).
Isotype
IgG2bκ
Species Reactivity
Human
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_002630
Gene Symbol
SERPINB5
PI5
Purification Method
Protein G Purified
UniProt Number
P36952
Molecular Weight
~42 kDa observed
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in HCT116 cell lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected SERPINB5 in 10 µg of HCT116 cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
