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Millipore Detect Mtss1 Using This Mouse Monoclonal Anti-Mtss1 Antibody, Clone 15c3.2, Cat. No. Mabc607, Validated For Use In Western Blotting And Immunohistochemistry (Paraffin). - Mill (Additional S&H or Hazmat Fees May Apply)
Metastasis suppressor protein 1 (UniProt O43312; also known as Metastasis suppressor YGL-1, Missing in metastasis protein) is encoded by the MTSS1 (also known as KIAA0429, MIM) gene (Gene ID 9788) in human. MTSS1 is a scaffold protein that regulates cytoskeletal dynamics and actin polymerization. MTSS1 is also reported to bind Gli proteins or the Gli-Sufu complex and potentiate the transcription of effector genes of the sonic hedgehog signaling pathway. MTSS1 is down-regulated in many metastatic cancer cells compared with their non-metastatic counterparts. MTSS1 expression is shown to be inversely correlated with the prognosis of solid carcinomas of the breast, liver, and bladder.
Product Information
Format
Purified
Presentation
Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Detect MTSS1 using this mouse monoclonal Anti-MTSS1 Antibody, clone 15C3.2, Cat. No. MABC607, validated for use in Western Blotting and Immunohistochemistry (Paraffin).
Key Applications
Western Blotting
Immunohistochemistry (Paraffin)
Application Notes
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected MTSS1 in human colon and human spleen tissues.
Biological Information
Immunogen
GST-tagged recombinant protein corresponding to the C-terminal of human MTSS1.
Epitope
C-terminal
Clone
15C3.2
Concentration
Please refer to lot specific datasheet.
Host
Mouse
Specificity
This clone is expected to react with all 4 spliced isoforms of human MTSS1.
Isotype
IgG2aκ
Species Reactivity
Human
Monkey
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_055566
Gene Symbol
MTSS1
KIAA0429
MIM
Purification Method
Protein G Purified
UniProt Number
O43312
Molecular Weight
~82 kDa observed
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in COS-1 cell lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected MTSS1 in 10 µg of COS-1 cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
