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CD39 (EC 3.6.1.5; also known as Ecto-apyrase, Ecto-ATPase 1, Ecto-ATPDase1 , Ecto-ATP diphosphohydrolase 1, Ectonucleoside triphosphate diphosphohydrolase 1, Lymphoid cell activation antigen, NTPDase 1) is encoded by the Entpd1 or Cd39 gene (Entrez Gene ID 12495) in murine species. CD39 is a cell surface nucleotide-metabolizing enzyme that hydrolyzes extracellular purine NTP and NDP. E. coli infection is reported to induce CD39 promoter activity in macrophages, resulting in an upregulated CD39 expression during sepsis in mice, while CD39 knockdown increases mortality among mice with polymicrobial sepsis (PMID 25318479). Anti-CD39, clone 5E12 binds the murine CD39 (P55772) extracellular domain and is demonstrated to selectively stain murine macroglia by flow cytometry (PMID 22863620).
Product Information
Format
Purified
Presentation
Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mm NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-CD39 Antibody, clone 5E12 is an antibody against CD39 for use in Flow Cytometry.
Key Applications
Flow Cytometry
Application Notes
Flow Cytometry Analysis: A representative lot detected CD39 in CD11b+ cells (Butovsky, O., et Al. (2012). J. Clin. Invest. 122(9):3063-3087).
Biological Information
Immunogen
Whole cells with surface CD39.
Epitope
extracellular domain
Clone
5E12
Concentration
1 mg/mL
Host
Rat
Isotype
IgG2aκ
Species Reactivity
Mouse
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_033978
Gene Symbol
Entpd1
Cd39
Purification Method
Protein g Purified
UniProt Number
P55772
Molecular Weight
70-100 kDa calculated
Product Usage Statements
Quality Assurance
Evaluated by Flow Cytometry in CD11b+ mouse splenocytes.
Flow Cytometry Analysis: Various dilutions of this antibody detected CD39 in CD11b+ mouse splenocytes.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
