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Millipore Anti-Iba1/Aif1 Antibody, Clone 20a12.1, Alexa Fluor® 555 Conjugate Is An Antibody Against Iba1/Aif1 For Use In Immunohistochemistry. - Mill (Additional S&H or Hazmat Fees May Apply)
Allograft inflammatory factor 1 (UniProt P55008; also known as AIF-1, Daintain, Interferon gamma responsive transcript, Ionized calcium-binding adapter molecule 1, Protein G1) is encoded by the AIF1 (also known as G1, IBA1) gene (Gene ID 199) in human. Iba1/AIF1 is a 17 kDa interferon-gamma- (IFN-gamma-) inducible, Ca(2+)-binding EF-hand protein. Iba1/AIF1 expression is mostly limited to the macrophage/monocyte lineage, and is augmented by cytokines, such as IFN-gamma. It is reported to be involved in neuronal function, inflammatory responses, allograft rejection, autoimmunity, and macrophage activation/function. It is also shown to be expressed in microglial cells in autominnume disesase models such as experimental autoimmune encephalomyelitis, neuritis and uveitis.
Product Information
Format
AlexaFluor®555
Presentation
Purified mouse antibody conjugate in PBS with 15 mg/mL BSA and 0.1 % sodium azide.
Quality Level
MQ100
Applications
Application
Anti-Iba1/AIF1 Antibody, clone 20A12.1, Alexa Fluor® 555 Conjugate is an antibody against Iba1/AIF1 for use in Immunohistochemistry.
Key Applications
Immunohistochemistry
Application Notes
The unconjugated antibody (Cat. No. MABN92) is shown to be suitable also for Western blotting and immunohistochemistry applications.
Biological Information
Immunogen
Linear peptide corresponding to a human Iba1/AIF1 sequence.
Clone
20A12.1
Concentration
Please refer to lot specific datasheet.
Host
Mouse
Isotype
IgG1κ
Species Reactivity
Human
Mouse
Rat
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_001614
Gene Symbol
AIF1
G1
IBA1
Purification Method
Protein g Purified
UniProt Number
P55008
Molecular Weight
~17 kDa observed
Product Usage Statements
Quality Assurance
Evaluated by Immunohistochemistry in human spleen tissue.
Immunohistochemistry Analysis: A 1:150 dilution of this antibody detected Iba1/AIF1 in human spleen tissue.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
