The store will not work correctly when cookies are disabled.
We use cookies to make your experience better.To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies.Learn about our cookie policy.
Millipore Detect Fgr Using This Mouse Monoclonal Anti-Fgr Antibody, Clone Sugr-7 14f3, Cat. No. Mabs1140, Validated For Use In Western Blotting. - Mill (Additional S&H or Hazmat Fees May Apply)
Tyrosine-protein kinase Fgr (EC 2.7.10.2; UniProt P09769; also known as c-fgr, c-src2, c-src-2 proto-oncogene, Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, p55-Fgr, p58-Fgr, p58c-Fgr, proto-oncogene c-Fgr) is encoded by the FGR (also known as SRC2) gene (Gene ID 2268) in human. Fgr is a member of the Src family of non-receptor protein tyrosine kinases (PTKs). Fgr contains N-terminal myristylation and palmitylation sites, a PTK catalytic domain, as well as SH2 and SH3 domains mediating interactions with phosphotyrosine-containing and proline-rich motifs, respectively. Fgr is a positive regulator of mast cell activation/degranulation and is essential for IgE-mediated passive cutaneous anaphylaxis (PCA) in mice. Fgr appears to act cooperatively with Fyn in the activation of Syk and its downstream targets in a manner that is counteracted by Lyn.
Product Information
Format
Purified
Presentation
Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mm NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Detect FGR using this mouse monoclonal Anti-Fgr Antibody, clone SuGr-7 14F3, Cat. No. MABS1140, validated for use in Western Blotting.
Key Applications
Western Blotting
Application Notes
Western Blotting Analysis: 1.0 µg/mL from a representative lot detected Fgr in 10 µg of Ramos cell lysate.
Biological Information
Immunogen
Recombinant protein corresponding to human Fgr.
Clone
SuGr-7 14F3
Concentration
Please refer to lot specific datasheet.
Host
Mouse
Isotype
IgG2aκ
Species Reactivity
Human
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_001036194
Gene Symbol
FGR
SRC2
Purification Method
Protein g Purified
UniProt Number
P09769
Molecular Weight
~59 kDa observed. Uncharacterized band(s) may appear in some lysates.
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in Daudi cell lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected Fgr in 10 µg of Daudi cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
