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Millipore Anti-Lox-1 Antibody, Clone 9e12.1 Is An Antibody Against Lox-1 For Use In Immunohistochemistry And Immunocytochemistry (Paraffin). - Mill (Additional S&H or Hazmat Fees May Apply)
Oxidized low-density lipoprotein receptor 1, soluble form
Background Information
LOX1 is a plasma membrane receptor, that also has a free soluble receptor form, that is the receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. LOX1 is also the receptor for HSP70, and LOX1 acts as a leukocyte adhesion molecule on glycosylated proteins present on platelets, monocytes, bacteria, apoptotic cells in inflammatory responses.
Product Information
Format
Purified
Presentation
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-LOX-1 Antibody, clone 9E12.1 is an antibody against LOX-1 for use in Immunohistochemistry and Immunocytochemistry (Paraffin).
Key Applications
Western Blotting
Immunohistochemistry (Paraffin)
Application Notes
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected LOX-1 in human placenta tissue.
Biological Information
Immunogen
GST-tagged recombinant protein corresponding to human LOX-1.
Clone
9E12.1
Concentration
Please refer to lot specific datasheet.
Host
Mouse
Isotype
IgG2aκ
Species Reactivity
Human
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_001166103
Gene Symbol
OLR1
CLEC8A
LOX1
Purification Method
Protein G Purified
UniProt Number
P78380
Molecular Weight
~35 kDa observed. The calculated molecular weight of this protein is 31 kDa, but can be observed at ~33-37 kDa due to high glycosylation.
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in KG-1 cell lysate.
Western Blotting Analysis: A 1:500 dilution of this antibody detected LOX-1 in 200 µg of KG-1 cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
