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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, M | ICC | M | AlexaFluor®488 | Monoclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | MABS519-AF488 |
| Description | Anti-P40 Antibody, clone 11F12.1, Alexa Fluor® 488 |
| Alternate Names |
|
| Background Information | Tumor protein 63 (UniProt Q9H3D4; also known as Amplified in squamous cell carcinoma, Chronic ulcerative stomatitis protein, CUSP, Keratinocyte transcription factor KET, p40, p51, p73L, TP63, Transformation-related protein 63, Tumor protein p73-like) is encoded by the TP63 (also known as KET, P63, P73H, P73L, TP73L) gene (Gene ID 8626) in human. Tumor protein 63 is a p53 homologue that can bind p53-responsive elements to upregulate some p53 target genes and share partially overlapping functions with p53. Various functions have been ascribed to TP63 in normal squamous epithelia, including those of the esophagus and TP63 is reported to play an essential role in the maintenance of proliferative potential in epithelial stem cells. TP63 overexpression is found in various squamous epithelia carcinomas and high TP63 expression is associated with an aggressive phenotype and metastasis in many cancers. |
| Product Information | |
|---|---|
| Format | AlexaFluor®488 |
| Presentation | Purified mouse conjugate antibody in PBS with 15 mg/ml BSA and 0.1 sodium azide. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | This Alexa Fluor® 488 conjugated Anti-P40 Antibody, clone 11F12.1, is validated for use in Immunocytochemistry (IHC) for the detection of P-40. |
| Key Applications |
|
| Application Notes | Immunocytochemistry Analysis: A 1:100 dilution from a representative lot detected P40 in HUVEC cells. The unconjugated version (Cat. No. MABS519) has been shown to work in WB, IH(P). |
| Biological Information | |
|---|---|
| Immunogen | KLH-conjugated linear peptide corresponding to human P40 near the N-terminus. |
| Epitope | Near N-terminus |
| Clone | 11F12.1 |
| Concentration | Please refer to lot specific datasheet. |
| Host | Mouse |
| Specificity | Expected to react with spliced isoform 2 (DeltaN-alpha, DeltaNp63 alpha, P51delNalpha), 4 (DeltaN-beta, DeltaNp63 beta, P51delNbeta), 6 (DeltaN-gamma, DeltaNp63gamma, P51delNgamma), 8 (DeltaN-delta), 10 (DeltaN-epsilon, DeltaNp73L), 12, but not isoform 1 (TA*-alpha, TAp63alpha, P51B), 3 (TA*-beta, TAp63beta), 5 (TA*-gamma, TAp63gamma, P51A), 7 (TA*-delta, TAp63delta, P51delta), 9 (TA*-epsilon), or 11 (P63 delta). |
| Species Reactivity |
|
| Antibody Type | Monoclonal Antibody |
| Entrez Gene Number |
|
| Gene Symbol |
|
| Purification Method | Protein G Purified |
| UniProt Number |
|
| Molecular Weight | ~40 kDa observed |
| Product Usage Statements | |
|---|---|
| Quality Assurance | Evaluated by Immunocytochemistry in NIH/3T3 cells. Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected P40 in NIH/3T3 cells. |
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Stable for 1 year at 2-8°C from date of receipt. |
| Packaging Information | |
|---|---|
| Material Size | 100 µL |