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Sigma-Aldrich Gentamicin Sulfate
List Price $620.40 Your Price $620.40
Sigma-Aldrich Gentamicin Sulfate - SIAL (Additional S&H Or Hazmat Fees May Apply)
NETA PART: SIAL-1289003-200MG
MFG.PART: 1289003-200MG
UNSPSC: 12350000
Manufacturer: Sigma-Aldrich
grade
pharmaceutical primary standard
API family
gentamicin
manufacturer/tradename
USP
application(s)
pharmaceutical (small molecule)
format
neat
SMILES string
O=S(O)(O)=O.O[C@]1(C)[C@@H]([C@@H](O)[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@H]3O[C@@](CC[C@H]3N)([C@@H](C)NC)[H])[C@@H](N)C[C@H]2N)OC1)NC.O[C@]4(C)[C@@H]([C@@H](O)[C@@H](O[C@@H]5[C@@H](O)[C@H](O[C@H]6O[C@@](CC[C@H]6N)([C@@H](C)N)[H])[C@@H](N)C[C@H]5N)OC4)NC.O[
InChI
1S/C21H43N5O7.C20H41N5O7.C19H39N5O7.H2O4S/c1-9(25-3)13-6-5-10(22)19(31-13)32-16-11(23)7-12(24)17(14(16)27)33-20-15(28)18(26-4)21(2,29)8-30-20;1-8(21)12-5-4-9(22)18(30-12)31-15-10(23)6-11(24)16(13(15)26)32-19-14(27)17(25-3)20(2,28)7-29-19;1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17;1-5(2,3)4/h9-20,25-29H,5-8,22-24H2,1-4H3;8-19,25-28H,4-7,21-24H2,1-3H3;8-18,24-27H,3-7,20-23H2,1-2H3;(H2,1,2,3,4)/t9-,10-,11+,12-,13+,14+,15-,16-,17+,18-,19-,20-,21+;8-,9-,10+,11-,12+,13+,14-,15-,16+,17-,18-,19-,20+;8-,9+,10-,11+,12-,13+,14+,15-,16+,17+,18+,19-;/m110./s1
InChI key
RDEIXVOBVLKYNT-HDZPSJEVSA-N
Related Categories
Pharmakopöestandards & Standards metrologischer Institute
Analytical Reference Standards
General description
Gentamicin Sulfate, consisting of sulfate salts, is a medication derived from antibiotic substances produced during the growth of Micromonospora purpurea bacterium. [1]
Application
Gentamicin sulfate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.
Also, for use with USP monographs such as:
Also, for use with USP monographs such as:
- Gentamicin Sulfate Cream
- Gentamicin Sulfate Ointment
- Gentamicin Sulfate Ophthalmic Ointment
- Gentamicin Sulfate Ophthalmic Solution
- Gentamicin Sulfate and Betamethasone Valerate Topical Solution
- Gentamicin Sulfate and Betamethasone Acetate Ophthalmic Solution
- Gentamicin Sulfate and Betamethasone Valerate Otic Solution
- Gentamicin and Prednisolone Acetate Ophthalmic Ointment
Biochem/physiol Actions
Mode of action: Gentamicin causes codon misreading by binding to the 30S ribosomal subunit, blocking the translocation of peptidyl-tRNA from the acceptor site to the donor site. The bactericidal effect of gentamicin on Pseudomonas aeruginosa is exerted by the binding of gentamicin to the outer membrane, where it displaces natural cations, destabilizes the membrane, and forms holes in the cell surface.
Antimicrobial spectrum: Includes Gram-negative and Gram-positive bacteria, including strains resistant to tetracycline, chloramphenicol, kanamycin and colistin, particularly strains of Pseudomonas, Proteus, Staphylococcus and Streptococcus.
Antimicrobial spectrum: Includes Gram-negative and Gram-positive bacteria, including strains resistant to tetracycline, chloramphenicol, kanamycin and colistin, particularly strains of Pseudomonas, Proteus, Staphylococcus and Streptococcus.
Caution
Sterile solutions should be stored at 2-8°C. Solutions have also been shown to be stable at room temperature and in boiling aqueous buffers of pH 2-142.
Analysis Note
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
Other Notes
This product is part of the USP Biologics program.
Legal Information
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
pictograms
GHS07
signalword
Warning
hcodes
H317
pcodes
P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
Hazard Classifications
Skin Sens. 1
wgk_germany
WGK 2
| SKU | SIAL-1289003-200MG |
|---|---|
| Supplier Part Number | 1289003-200MG |
| UM | EA |
| UNSPSC | 12350000 |
| Manufacturer | Sigma-Aldrich |
| Temperature | F0 |
| ProductLine | SIAL |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 9 |
| Hazardous | Y |
| CAS Number | 1405-41-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |