Sigma-Aldrich Pancuronium Dibromide - Ca

Assay

≥98% (NMR)

Quality Level

100

Form

solid

Potency

5.5 nM IC₅₀

Manufacturer/Tradename

Calbiochem^®

Storage Condition

OK to freeze
protect from light

Color

off-white

Solubility

water: 100 mm

Storage Temp.

2-8°C

Inchi

1S/C35H60N2O4.2BrH/c1-24(38)40-32-21-26-13-14-27-28(35(26,4)23-31(32)37(6)19-11-8-12-20-37)15-16-34(3)29(27)22-30(33(34)41-25(2)39)36(5)17-9-7-10-18-36;;/h26-33H,7-23H2,1-6H3;2*1H/q+2;;/p-2/t26-,27+,28-,29-,30-,31-,32-,33-,34-,35-;;/m0../s1

General Description

A highly potent competitive antagonist selective for nAChRs (IC₅₀= 5.5 nM). A very potent non-depolarizing skeletal muscle relaxant but no sedative or analgesic effects.

Biochem/Physiol Actions

Primary Target
nAChR

Warning

Toxicity: Toxic (F)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Lowenick et Al., 2001.Eur. J. Pharmacol. 413,31.

Melnikov, L., et Al., 1999.Gen Pharmacol. 33,313.

Maestrone, E., et Al., 1994.Br. J. Pharmacol. 111,283.

Fryer, D., et Al., 1987.Naunyn Schmiedebergs Arch. Pharmacol. 335,367.CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, GermanyGHS06H301P264 - P270 - P301 + P310 - P405 - P501