Sigma-Aldrich Bupropion Hydrochloride

Assay

≥99% (HPLC)

Quality Level

100

Form

solid

Potency

1.4 μM K_i

Manufacturer/Tradename

Calbiochem^®

Storage Condition

OK to freeze
protect from light

Color

white

Solubility

water: soluble

Storage Temp.

2-8°C

Inchi

1S/C13H18ClNO.ClH/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10;/h5-9,15H,1-4H3;1H

General Description

A non-selective inhibitor of dopamine and noradrenalin transporters (K_i= 1.4, 2.8 and 45 µM for dopamine, noradrenalin, and serotonin transporters respectively). Also an antagonist for neuronal nicotinic acetylcholine receptors (nAChrs) (IC₅₀= 1.8 µM at α2β2 receptor). Clinically used as an antidepressant and smoking seceasion drug. Used in nicotinic addiction and depression studies.

Biochem/Physiol Actions

Primary Target
DAT/NET

Warning

Toxicity: Harmful (C)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Budzynska, B. et Al. 2011Pharmacol. Rep. 63,71.

Dwoskin, P., et Al. 2006.CNS Drug Rev. 12,178.
Soroko, F., et Al. 1977.J. Pharm. Pharmacol. 29,769.CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, GermanyGHS07H302P264 - P270 - P301 + P312 - P501