Sigma-Aldrich Pyoxim Novabiochem(R)

Quality Level

300

Product Line

Novabiochem^®

Assay

≥99.0% (HPLC)

Form

powder

Reaction Suitability

reaction type: Coupling Reactions

Manufacturer/Tradename

Novabiochem^®

Application(S)

peptide synthesis

Storage Temp.

15-25°C

Inchi

1S/C17H29N5O3P.F6P/c1-2-24-17(23)16(15-18)19-25-26(20-9-3-4-10-20,21-11-5-6-12-21)22-13-7-8-14-22;1-7(2,3,4,5)6/h2-14H2,1H3;/q+1;-1/b19-16+;

Inchi Key

RDWDVLFMPFUBDV-PXMDEAMVSA-N

Related Categories

Amino Acids, Resins & Reagents for Peptide Synthesis

General Description

PyOxim is a novel reagent which mediates coupling reactions with efficiencies superior to HATU and PyBOP and comparable to COMU. It is has excellent solubility in DMF and is stable in solution under an inert atmosphere for two days. Unlike HATU and HBTU, it cannot cause chain terminating side reactions and is, therefore, ideal for the synthesis of cyclic peptides. Furthermore, it is not explosive under normal operating conditions and is less likely to exhibit allergenicity compared to other coupling reagents.


Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents

Literature references

R. Subiros-Funosas, et Al.(2010)Org. Biomol. Chem.,8, 3665.

Features And Benefits

• Mediates coupling with superior efficiency to PyBOP, TBTU, and HCTU
• Mediates coupling with low racemization or epimerization
• Ideal for fragment condensation and synthesis of cyclic peptides as the reagent cannot cause guanidinylation
• Excellent solubility in DMF and NMP

Analysis Note

Colour (visual): white to off white
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 99.0 %
Solubility (1 mmole in 2 mL DMF): clearly solubleNovabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany