Sigma-Aldrich Fmoc-Pen(Trt)-Oh Novabioch

Quality Level

200

Product Line

Novabiochem^®

Assay

≥98% (TLC)
≥98.0% (HPLC)

Form

powder

Reaction Suitability

reaction type: Fmoc solid-phase peptide synthesis

Manufacturer/Tradename

Novabiochem^®

Application(S)

peptide synthesis

Functional Group

thiol

Storage Temp.

15-25°C

Inchi

1S/C39H35NO4S/c1-38(2,45-39(27-16-6-3-7-17-27,28-18-8-4-9-19-28)29-20-10-5-11-21-29)35(36(41)42)40-37(43)44-26-34-32-24-14-12-22-30(32)31-23-13-15-25-33(31)34/h3-25,34-35H,26H2,1-2H3,(H,40,43)(H,41,42)/t35-/m1/s1

Related Categories

Amino Acids, Resins & Reagents for Peptide Synthesis

General Description

Fmoc-Pen(Trt)-OH is the standard building block for the introduction of penicillamine amino-acid residues by Fmoc SPPS. The side-chain thiol protecting group (Trt) is removed during the standard TFA-mediated cleavage reaction.

Associated Protocols and Technical Articles:
Cleavage and Deprotection Protocols for Fmoc SPPS

Application

Fmoc-Pen(Trt)-OH has been recently used in the synthesis of disulfide surrogate peptides.

Analysis Note

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(0811)): ≥ 98 %
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 mL DMF): clearly soluble

To see the solvent systems used for TLC of Novabiochem^®products please click here.Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany