Revvity Integrisense 645 Fluores

Revvity Integrins Are Transmembrane Cell Surface Receptors Which Mediate Signal Transduction, Cell-To-Cell Interaction And Cell-To Extracellular Matrix Adhesion, Key Processes Involved In Angiogenesis, Tumorigenesis And Metastasis. Integrins Have Thus Been Hailed As Clinically-Relevant Biomarkers Of Pathological Conditions Such As Inflammation And Tumor Progression. The IntegrinAvb3Is Significantly Upregulated In Tumor Cells And Activated Endothelial Cells During Neoangiogenesis. Integrisense 645 Fluorescent Imaging Agent Is Used For In Vivo Detection Of Avb3 Using A Low Molecular Weight Peptidomimetic Antagonist Coupled To A Red Fluorochrome. Integrisense 645, An Integrin-Targeted Molecular Imaging Agent Allows The Non-Invasive Imaging Of Disease Status And Progression. Pairing Of An Integrin Antagonist Treatment With Integrisense 645 Provides A Mechanistic Biomarker Approach For Assessing Target Coverage - PEGSK (Additional S&H Or Hazmat Fees May Apply)