Revvity Integrisense 680 Fluores

Revvity Integrins Are Transmembrane Cell Surface Receptors Which Mediate Signal Transduction, Cell-To-Cell Interaction And Cell-To Extracellular Matrix Adhesion, Key Processes Involved In Angiogenesis, Tumorigenesis And Metastasis. Integrins Have Thus Been Hailed As Clinically-Relevant Biomarkers Of Pathological Conditions Such As Inflammation And Tumor Progression. The Integrin Avb3 Is Significantly Upregulated In Tumor Cells And Activated Endothelial Cells During Neoangiogenesis. Integrisense 680 Fluorescent Imaging Agent Is Used For In Vivo Detection Of Avb3 Using A Low Molecular Weight Peptidomimetic Antagonist Coupled To A Red Fluorochrome. Integrisense 680, An Integrin-Targeted Molecular Imaging Agent Allows The Non-Invasive Imaging Of Disease Status And Progression. Pairing Of An Integrin Antagonist Treatment With Integrisense 680 Provides A Mechanistic Biomarker Approach For Assessing Target Coverage - PEGSK (Additional S&H Or Hazmat Fees May Apply)