Revvity Fluorescent Imaging Agent Panel - Arthritis

Revvity The biology of arthritis is complex, involving multiple cellular players, secreted factors, and processes that can lead to sever joint damage. Our fluorescent imaging probes targeting arthritis research allows in vivo imaging of the magnitude of inflammation, bone destruction, cartilage degradation, and vascular leak (edema) in a manner that non-invasively predicts the underlying histopathology of this disease. The availability of probes at 680 nm and 750 nm wavelengths further offer the opportunity for multiplex imaging of appropriate probe combinations to maximize information gained from research animals.  The Arthritis In Vivo Fluorescent Agents Panel includes the following six probes: Part Number Fluorescent Probe Biological Target NEV10003 ProSense 680 Pan-cathepsin activatable probe: Lysosomal marker of inflammatory cells NEV10011EX AngioSense 750 EX Vascular probe: Leaks into sites of edema NEV10020EX OsteoSense 680 EX Bone turnover targeted probe: Detects areas of exposed hydroxyapatite NEV10126 MMPSense 680 Pan-MMP activatable probe: Secreted marker of inflammatory cells, bone/cartilage degradation NEV11000 CAT K 680 FAST Cathepsin K activatable probe: Secreted marker of osteoclasts, bone degradation NEV11098 CAT B 750 FAST Cathepsin B activatable probe: Lysosomal marker of inflammatory cells - PEMSD (Additional S&H or Hazmat Fees May Apply)