Revvity Fluorescent Imaging Agent Panel - Oncology

Revvity Cancer involves the spontaneous emergence of cells that lose their ability regulate their cell growth and proliferation. However, the biology of cancer is much more complex than just the presence of tumor cells, involving a tumor microenvironment comprised of neovasculature, stromal cells, and inflammatory cells, as well as regions of hypoxia, necrosis, and vascular leak. Our fluorescent imaging probes provide a variety of tools for quantifying key receptors or proteins associated with tumor burden, metabolism, inflammation, protease activity and vascular leak. The availability of probes at 680 nm and 750 nm wavelengths further offer the opportunity for multiplex imaging of appropriate probe combinations to maximize information gained from research animals. The Oncology In Vivo Fluorescent Agents Panel includes the following five probes: Part Number Fluorescent Probe Biological Target NEV10001EX ProSense 750 EX Pan-cathepsin activatable probe: Lysosomal marker of a variety of inflammatory cells NEV10040 FolateRSense 680 Folate receptor targeted probe: Marker on inflammatory cells; metabolic marker on tumor cells NEV10054EX AngioSense 680 EX Vascular probe: Leaks into sites of neovascular formation NEV10168 MMPSense 750 FAST Pan-MMP activatable probe: Secreted protease from inflammatory cells and tumor cells NEV10873 IntegriSense 750 V3 integrin targeted probe: Marker on activated tumors and neovasculature - PEMSD (Additional S&H or Hazmat Fees May Apply)