Revvity Fluorescent Imaging Agent Panel - Inflammation

Revvity Inflammation is a complex biological response to stimuli presented by pathogens, tissue damage, or local irritants and involves a variety of immune cells that work to remove and repair the original insult and damaged tissue regions. Our fluorescent imaging probes provide a variety of tools for quantifying inflammatory biology (various proteases or upregulated receptors) as well as detecting and measuring the edema response. The ability to non-invasively quantify inflammation biology in vivo offers greater opportunity for longitudinal studies and understanding disease pathogenesis in the context of intact animal physiology. The availability of probes at 680 nm and 750 nm wavelengths further offer the opportunity for multiplex imaging of appropriate probe combinations to maximize information gained from research animals. The Inflammation In Vivo Fluorescent Agents Panel includes the following six probes: Part Number Fluorescent Probe Biological Target NEV10054EX AngioSense 680 EX Vascular probe: Leaks into sites of edema NEV10168 MMPSense 750 FAST Pan-MMP activatable probe: Secreted marker of neutrophils, macrophages, and mast cells NEV10040 FolateRSense 680 Folate receptor targeted probe: Marker on activated neutrophils and macrophages NEV10873 IntegriSense 750 V3 integrin targeted probe: Marker on activated macrophages NEV11169 Neutrophil Elastase 680 FAST Neutrophil elastase activatable probe: Secreted protease from neutrophils NEV11171 ProSense 750 FAST Pan-cathepsin activatable probe: Lysosomal marker of a variety of inflammatory cells - PEMSD (Additional S&H or Hazmat Fees May Apply)