Revvity Fluorescent Imaging Agent Panel - Tumor Metabolism

Revvity Tumors modify the cellular metabolism in cancer cells when compared to normal healthy cells. They alter pathways of nutrient acquisition and metabolism to meet increased energy, synthetic, and proliferative demands. Biomarkers of tumor metabolism offer not only opportunities to study tumor progression but also to specifically assess therapies that target critical pathways in tumor metabolism. Our fluorescent imaging probes provide a variety of tools for quantifying key receptors associated with proliferation and nutrient uptake as well as biomarkers of cell death, protease activity, and vascular leak. The availability of probes at 680 nm and 750 nm wavelengths further offer the opportunity for multiplex imaging of appropriate probe combinations to maximize information gained from research animals.  The Tumor Metabolism In Vivo Fluorescent Agents Panel includes the following seven probes: Part Number Fluorescent Probe Biological Target NEV10054EX AngioSense 680 EX Vascular probe: Leaks into sites of edema NEV10168 MMPSense 750 FAST Pan-MMP activatable probe: Secreted marker of neutrophils, macrophages, and mast cells NEV10003 ProSense 680 Pan-cathepsin activatable probe: Lysosomal marker of a variety of inflammatory cells NEV10040 FolateRSense 680 Folate receptor targeted probe: Marker on inflammatory cells; metabolic marker on tumor cells NEV10090 BombesinRSense 680 Bombesin receptor targeted probe: Metabolic marker on tumor cells NEV10091 Transferrin-Vivo 750 Transferrin receptor targeted probe: Iron metabolism marker on tumor cells NEV11053 Annexin-Vivo 750 Death/apoptosis probe: Detects surface phosphatidylserine increase on dying cells - PEMSD (Additional S&H or Hazmat Fees May Apply)