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200 µg of protein g purified mouse IgG1 in 200 µL of storage buffer (0.02 M phosphate buffer, pH 7.6, 0.25 M NaCl, and 0.1% sodium azide. Frozen at -20°C.
Quality Level
MQ100
Applications
Application
Detect MAP2 using this Anti-MAP2 Antibody, clone 5F9 validated for use in WB, IH.
Key Applications
Western Blotting
Immunohistochemistry
Biological Information
Immunogen
Purified rat brain microtubules MAP2
Clone
clone 5F9
Host
Mouse
Specificity
MAP2
Isotype
IgG1
Species Reactivity
Human
Mouse
Rat
Rabbit
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NM_013066.1
Entrez Gene Summary
The MAP2 gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described.
Gene Symbol
Map2
Mtap2
Purification Method
Protein g Chromatography
UniProt Number
P15146
UniProt Summary
FUNCTION: SwissProt: P15146 # MAP2 is a neuron-specific protein that stabilizes microtubules in the dendrites of postmitotic neurons. Its major fucnction is to stabilize neuronal shape by promoting microtubule synthesis and cross-linking with other components of the cytoskelton. SIZE: 1,861 amino acids (Isofoim 1); 1830 amino acids (Isofoim 2); 467 amino acids (Isofoim 3); 498 amino acids (Isofoim 4) SUBCELLULAR LOCATION: Cytoplasm. Cytoskeleton. PTM: Phosphorylated at serine residues in K-X-g-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly.
Molecular Weight
202.41 kDa
Product Usage Statements
Quality Assurance
routinely evaluated on rat brain microsomal preparation (Catalog #12-144).
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
